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A novel paradigm to investigate regulation of drug intake in rats self-administering cocaine or heroin intravenously.

Authors
  • Lynch, W J
  • LaBounty, L P
  • Carroll, M E
Type
Published Article
Journal
Experimental and clinical psychopharmacology
Publication Date
Feb 01, 1998
Volume
6
Issue
1
Pages
22–31
Identifiers
PMID: 9526143
Source
Medline
License
Unknown

Abstract

The purpose of this experiment was to investigate the regulation of drug intake in rats (n = 20) self-administering heroin or cocaine during daily 5-hr sessions. Operant chambers were equipped with 2 levers and associated stimulus lights. A response on the lever with stimuli signaling an increase in dose size increased the infusion duration by 3 s, and a response on the lever with stimuli signaling a decrease in dose size decreased the infusion duration by 3 s. Results showed that daily and hourly drug intake for cocaine and heroin groups were relatively constant. Significant correlation coefficients were obtained for heroin and cocaine groups for the relationship between interdose interval (IDI) and infusion duration (dose size). These findings indicate that subjects regulated their drug intake by adjusting IDI throughout drug self-administration sessions.

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