Affordable Access

deepdyve-link
Publisher Website

A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models.

Authors
  • Rorick-Kehn, Linda M1
  • Ciccocioppo, Roberto2
  • Wong, Conrad J1
  • Witkin, Jeffrey M1
  • Martinez-Grau, Maria A3
  • Stopponi, Serena2
  • Adams, Benjamin L1
  • Katner, Jason S1
  • Perry, Kenneth W1
  • Toledo, Miguel A3
  • Diaz, Nuria3
  • Lafuente, Celia3
  • Jiménez, Alma3
  • Benito, Ana3
  • Pedregal, Concepción3
  • Weiss, Friedbert4
  • Statnick, Michael A1
Type
Published Article
Journal
Alcoholism Clinical and Experimental Research
Publisher
Wiley (Blackwell Publishing)
Publication Date
Apr 30, 2016
Volume
40
Issue
5
Pages
945–954
Identifiers
DOI: 10.1111/acer.13052
PMID: 27084498
Source
Medline
Keywords
License
Unknown

Abstract

Our findings demonstrate for the first time that blockade of NOP receptors attenuates ethanol self-administration and ethanol-motivated behaviors, stress-induced ethanol seeking, and ethanol-induced stimulation of brain reward pathways in lines of rats that exhibit excessive ethanol consumption. Results suggest that LY2940094 may have potential therapeutic utility in treating alcohol addiction.

Report this publication

Statistics

Seen <100 times