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Novel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effect.

Authors
  • Choi, Jong Seo1
  • Kim, Dong Wuk1
  • Kim, Dong Shik1
  • Kim, Jong Oh2
  • Yong, Chul Soon2
  • Cho, Kwan Hyung3
  • Youn, Yu Seok4
  • Jin, Sung Giu1
  • Choi, Han-Gon1
  • 1 a College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University , Ansan , South Korea.
  • 2 b College of Pharmacy, Yeungnam University , Gyongsan , South Korea.
  • 3 c College of Pharmacy, Inje University , Gimhae , South Korea , and.
  • 4 d School of Pharmacy, Sungkyunkwan University , Suwon , South Korea.
Type
Published Article
Journal
Drug delivery
Publication Date
October 2016
Volume
23
Issue
8
Pages
2806–2812
Identifiers
PMID: 26394193
Source
Medline
Keywords
License
Unknown

Abstract

To develop a novel neomycin sulfate-loaded hydrogel dressing (HD), numerous neomycin sulfate-loaded HDs were prepared with various amounts of polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) and sodium alginate (SA) using freeze-thawing technique, and their physical dressing properties, drug release, in vivo wound curing and histopathology in diabetic-induced rats were assessed. SA had a positive effect on a swelling capacity, but a negative effect on the physical dressing properties and drug release of HD. However, PVP did the opposite. In particular, the neomycin sulfate-loaded HD composed of drug, PVA, PVP and SA at the weight ratio of 1/10/0.8/0.8 had excellent swelling and bioadhesive capacity, good elasticity and fast drug release. Moreover, this HD gave more improved wound curing effect compared to the commercial product, ensured the disappearance of granulation tissue and recovered the wound tissue to normal. Therefore, this novel neomycin sulfate-loaded HD could be an effective pharmaceutical product for the treatment of wounds.

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