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Novel Negative Sense Genes in the RNA Genome of Coronaviruses

Authors
  • Zhirnov, O. P.1, 2
  • Poyarkov, S. V.1
  • 1 Russian–German Academy of Medico-Social and Biotechnological Sciences, Moscow, Russia , Moscow (Russia)
  • 2 Ivanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Moscow, Russia , Moscow (Russia)
Type
Published Article
Journal
Doklady Biochemistry and Biophysics
Publisher
Pleiades Publishing
Publication Date
Mar 10, 2021
Volume
496
Issue
1
Pages
27–31
Identifiers
DOI: 10.1134/S1607672921010130
Source
Springer Nature
Keywords
License
Yellow

Abstract

AbstractThe coronavirus family consists of lipid-containing envelope viruses that have a single-stranded RNA genome that encodes 25–30 proteins in different viruses by the mechanism of positive-polarity strategy. In addition, extended open reading trnslation frames (ORFs, genes) located in a negative-sense orientation were found in the genomes of coronaviruses. The size of negative-sense genes varies in the range of 150–450 nt, which corresponds to polypeptides encoded by negative-polarity genes (negative gene proteins, NGP) with m. m. 5–30 × 103 kDa. Coronaviruses show marked differences from virus to virus in the number of negative genes detected. These negative-sense genes in the coronavirus genome allow this family to be considered as viruses developing an ambisense genome strategy.

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