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A novel method for quantitative determination of aceclofenac in bulk drug and tablets using sodium salicylate as a hydrotropic solubilizing agent.

Authors
  • Maheshwari, R K
  • Moondra, Shruti
Type
Published Article
Journal
Journal of advanced pharmaceutical technology & research
Publication Date
Jan 01, 2010
Volume
1
Issue
1
Pages
78–82
Identifiers
PMID: 22247834
Source
Medline
Keywords
License
Unknown

Abstract

In titrimetric analysis costlier organic solvents are more often employed to solubilize the poorly water-soluble drugs. Volatility and pollution are drawbacks of such solvents. Various techniques are employed to enhance the aqueous solubility of poorly water-soluble drugs. Hydrotropic solubilization phenomenon has been widely used to enhance the aqueous solubility of large number of poorly water-soluble drugs. Aqueous solubility of aceclofenac bulk drug [a poorly water-soluble NSAID] was enhanced to a great extent i.e., 400 folds with 2.5 M sodium salicylate. The primary objective of the present investigation was to employ this hydrotropic solution to extract the drug from its dosage forms, precluding the use of costlier organic solvents. The proposed method of analysis is new, simple, accurate, environmentally friendly and reproducible. Statistical data proved the accuracy, reproducibility and the precision of the proposed method. The results of titrimetric analysis by use of hydrotropy compared very well with the results of Pharmacopoeial method.

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