Affordable Access

A novel method for the one-pot five-component synthesis of highly functionalized pyranopyrazoles catalyzed by CuI nanoparticles.

Authors
  • Safaei-Ghomi, Javad
  • Ziarati, Abolfazl
  • Tamimi, Mehrnoush
Type
Published Article
Journal
Acta chimica Slovenica
Publication Date
Jan 01, 2013
Volume
60
Issue
2
Pages
403–410
Identifiers
PMID: 23878946
Source
Medline
License
Unknown

Abstract

A novel one-pot, five-component reaction for the synthesis of highly functionalized pyranopyrazoles from acid chlorides, Meldrum's acid, hydrazine hydrate, aromatic aldehydes and malononitrile in the presence of catalytic amount of CuI nanoparticles in aqueous media is reported. This method provides several benefits such as in situ preparation of beta-ketoester, mild reaction conditions, and environmentally friendly, waste-free and simple work-up procedure with excellent yields. The catalyst could be recovered and reused for several times with almost consistent catalytic activity.

Report this publication

Statistics

Seen <100 times