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The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics.

Authors
  • Xiong, Mingchen1
  • Zhang, Qi2
  • Hu, Weijie3
  • Zhao, Chongru1
  • Lv, Wenchang1
  • Yi, Yi1
  • Wang, Yichen1
  • Tang, Hongbo4
  • Wu, Min5
  • Wu, Yiping6
  • 1 Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. , (China)
  • 2 Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected] , (China)
  • 3 Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected] , (China)
  • 4 Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected] , (China)
  • 5 Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected] , (China)
  • 6 Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Pharmacological Research
Publisher
Elsevier
Publication Date
Apr 01, 2021
Volume
166
Pages
105490–105490
Identifiers
DOI: 10.1016/j.phrs.2021.105490
PMID: 33582246
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Exposure to the external environment may lead to instability and dysfunction of the skin, resulting in refractory wound, skin aging, pigmented dermatosis, hair loss, some immune-mediated dermatoses, and connective tissue diseases. Nowadays, many skin treatments have not achieved a commendable balance between medical recovery and cosmetic needs. Exosomes are cell-derived nanoscale vesicles carrying various biomolecules, including proteins, nucleic acids, and lipids, with the capability to communicate with adjacent or distant cells. Recent studies have demonstrated that endogenic multiple kinds of exosomes are crucial orchestrators in shaping physiological and pathological development of the skin. Besides, exogenous exosomes, such as stem cell exosomes, can serve as novel treatment options to repair, regenerate, and rejuvenate skin tissue. Herein, we review new insights into the role of endogenic and exogenous exosomes in the skin microenvironment and recent advances in applications of exosomes related to dermatology and cutaneous medical aesthetics. The deep understanding of the mechanisms by which exosomes perform biological functions in skin is of great potential to establish attractive therapeutic methods for the skin. Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

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