The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics.
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Authors
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Xiong, Mingchen1
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Zhang, Qi2
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Hu, Weijie3
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Zhao, Chongru1
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Lv, Wenchang1
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Yi, Yi1
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Wang, Yichen1
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Tang, Hongbo4
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Wu, Min5
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Wu, Yiping6
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1
Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China.
,
(China)
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2
Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected]
,
(China)
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3
Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected]
,
(China)
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4
Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected]
,
(China)
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5
Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected]
,
(China)
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6
Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China. Electronic address: [email protected]
,
(China)
- Type
- Published Article
- Journal
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Pharmacological Research
- Publisher
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Elsevier
- Publication Date
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Apr 01, 2021
- Volume
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166
- Pages
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105490–105490
- Identifiers
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DOI: 10.1016/j.phrs.2021.105490
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PMID: 33582246
- Source
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Medline
- Keywords
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- Language
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English
- License
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Unknown
Abstract
Exposure to the external environment may lead to instability and dysfunction of the skin, resulting in refractory wound, skin aging, pigmented dermatosis, hair loss, some immune-mediated dermatoses, and connective tissue diseases. Nowadays, many skin treatments have not achieved a commendable balance between medical recovery and cosmetic needs. Exosomes are cell-derived nanoscale vesicles carrying various biomolecules, including proteins, nucleic acids, and lipids, with the capability to communicate with adjacent or distant cells. Recent studies have demonstrated that endogenic multiple kinds of exosomes are crucial orchestrators in shaping physiological and pathological development of the skin. Besides, exogenous exosomes, such as stem cell exosomes, can serve as novel treatment options to repair, regenerate, and rejuvenate skin tissue. Herein, we review new insights into the role of endogenic and exogenous exosomes in the skin microenvironment and recent advances in applications of exosomes related to dermatology and cutaneous medical aesthetics. The deep understanding of the mechanisms by which exosomes perform biological functions in skin is of great potential to establish attractive therapeutic methods for the skin. Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 01/14/2022 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at
https://www.ncbi.nlm.nih.gov/pubmed/33582246
