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A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas.

Authors
Type
Published Article
Journal
Cytogenetics and cell genetics
Publication Date
Volume
95
Issue
3-4
Pages
153–156
Identifiers
PMID: 12063392
Source
Medline
License
Unknown

Abstract

The lipoma preferred partner (LPP) gene is fused to the high mobility group protein gene HMGIC in lipomas and pulmonary chondroid hamartomas. In addition, a fusion of LPP to the mixed lineage leukemia (MLL) gene has been described in a case of acute myeloid leukemia. Herein, a novel LPP fusion transcript of LPP in a lipoma is described that points to the possible oncogenic potential of LPP.

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