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A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas.

Authors
  • Lemke, I
  • Rogalla, P
  • Bullerdiek, J
Type
Published Article
Journal
Cytogenetics and cell genetics
Publication Date
Jan 01, 2001
Volume
95
Issue
3-4
Pages
153–156
Identifiers
PMID: 12063392
Source
Medline
License
Unknown

Abstract

The lipoma preferred partner (LPP) gene is fused to the high mobility group protein gene HMGIC in lipomas and pulmonary chondroid hamartomas. In addition, a fusion of LPP to the mixed lineage leukemia (MLL) gene has been described in a case of acute myeloid leukemia. Herein, a novel LPP fusion transcript of LPP in a lipoma is described that points to the possible oncogenic potential of LPP.

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