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Novel hollow microneedle technology for depth-controlled microinjection-mediated dermal vaccination: a study with polio vaccine in rats.

Authors
  • van der Maaden, Koen
  • Trietsch, Sebastiaan J
  • Kraan, Heleen
  • Varypataki, Eleni Maria
  • Romeijn, Stefan
  • Zwier, Raphäel
  • van der Linden, Heiko J
  • Kersten, Gideon
  • Hankemeier, Thomas
  • Jiskoot, Wim
  • Bouwstra, Joke
Type
Published Article
Journal
Pharmaceutical Research
Publisher
Springer-Verlag
Publication Date
Jul 01, 2014
Volume
31
Issue
7
Pages
1846–1854
Identifiers
DOI: 10.1007/s11095-013-1288-9
PMID: 24469907
Source
Medline
License
Unknown

Abstract

We successfully developed a hollow microneedle technology for dermal vaccination that enables fundamental research on factors, such as insertion depth and volume, and insertion angle, on the immune response.

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