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Novel HLA-DRB1 alleles revealed by sequencing based typing, DRB1*04053 and DRB1*1143.

Authors
  • Greville, W D
  • Chapman, G
  • Hogbin, J-P
  • Dunckley, H
Type
Published Article
Journal
Tissue antigens
Publication Date
Apr 01, 2002
Volume
59
Issue
4
Pages
347–349
Identifiers
PMID: 12135441
Source
Medline
License
Unknown

Abstract

We report the discovery of two HLA-DRB1 alleles by sequencing based typing (SBT). DRB1*04053 differs from previously reported DRB1 alleles by a single synonymous nucleotide substitution, resulting in a unique polymorphism at codon 93. DRB1*1143 differs from previously identified DRB1 alleles by a single non-synonymous nucleotide substitution, resulting in a polymorphism observed in other DRB1 and DRB3 alleles1.

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