Affordable Access

A novel GTP gamma S-dependent regulatory mechanism in the basolateral Cl- channel of gastric parietal cells.

Authors
  • Sakai, H
  • Kakinoki, B
  • Takeguchi, N
Type
Published Article
Journal
The Japanese journal of physiology
Publication Date
Jan 01, 1994
Volume
44 Suppl 2
Identifiers
PMID: 7752545
Source
Medline
License
Unknown

Abstract

A housekeeping basolateral Cl- channel in rabbit gastric parietal cells (0.3-0.4 pS) is closed by an intracellular application of GTP gamma S. Here, we found a novel GTP gamma S-dependent regulatory mechanism, in which GTP gamma S stimulates intracellular superoxide (O2-) production and the O2- acts as a messenger in the closure of the Cl- channel. Other oxygen species such as .OH and H2O2 were not involved in the closing mechanism.

Report this publication

Statistics

Seen <100 times