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A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction.

Authors
  • Wang, Meng
  • Tan, Cun
  • He, Qian
  • Xie, Yuyuan
  • Yang, Chunhao
Type
Published Article
Journal
Organic & Biomolecular Chemistry
Publisher
The Royal Society of Chemistry
Publication Date
Apr 28, 2013
Volume
11
Issue
16
Pages
2574–2577
Identifiers
DOI: 10.1039/c3ob40157j
PMID: 23487245
Source
Medline
License
Unknown

Abstract

A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.

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