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A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives.

Authors
  • Fan, G
  • Mar, W
  • Park, M K
  • Choi, E W
  • Kim, K
  • Kim, S
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Sep 03, 2001
Volume
11
Issue
17
Pages
2361–2363
Identifiers
PMID: 11527731
Source
Medline
License
Unknown

Abstract

A series of umbelliferone derivatives was prepared and their 5alpha-reductase type 1 inhibitory activities were evaluated in cell culture systems. Our studies have identified a new series of potent 5alpha-reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated with overproduction of DHT by 5alpha-reductase type 1. The preliminary structure-activity relationship was described to elucidate the essential structural requirements.

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