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Novel class of hybrid natural products as antidiabetic agents.

Authors
  • Raj, Kanwal
  • Misra, Namita
  • Pachauri, Geetali
  • Sharma, Mithelesh
  • Tamrakar, Akhilesh Kumar
  • Singh, Amar Bahadur
  • Srivastava, Arvind Kumar
  • Phani Kiran, K
  • Narasimha Rao, C V
  • Prubhu, S R
Type
Published Article
Journal
Natural product research
Publication Date
Jan 01, 2009
Volume
23
Issue
1
Pages
60–69
Identifiers
DOI: 10.1080/14786410701824940
PMID: 19140071
Source
Medline
License
Unknown

Abstract

A number of O-alkylated xanthone, carbazoles and coumarins have been synthesised and screened for their in vitro anti-diabetic activity, such as glucose-6-phosphatase, glycogen phosphorylase and alpha glucosidase inhibitors. Compounds which were showing significant percentage inhibition were also tested for in vivo anti-hyperglycemic activity in sucrose loaded normal and streptozotocin (STZ)-induced diabetic rats. These compounds show 22.1, 24.4 and 26.7% and 20.8, 25.0, 20.5% lowering in sucrose loaded normal rats and STZ-induced diabetic rats at a dose of 100 mg kg(-1).

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