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Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation.

Authors
  • Verma, Subodh
  • Maitland, Andrew
  • Weisel, Richard D
  • Fedak, Paul W M
  • Pomroy, Neil C
  • Li, Shu-Hong
  • Mickle, Donald A G
  • Li, Ren-Ke
  • Rao, Vivek
Type
Published Article
Journal
Journal of Thoracic and Cardiovascular Surgery
Publisher
American Association for Thoracic Surgery
Publication Date
Jun 01, 2002
Volume
123
Issue
6
Pages
1074–1083
Identifiers
PMID: 12063453
Source
Medline
License
Unknown

Abstract

Supplemental tetrahydrobiopterin provides a novel cardioprotective effect on left ventricular function, endothelial-vascular reactivity, oxidative damage, and cardiomyocyte injury after ischemia-reperfusion injury and might represent an important cellular target for future operative myocardial protection strategies.

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