Novel Brugada syndrome-causing mutation in ion-conducting pore of cardiac Na+ channel does not affect ion selectivity properties.

A S Amin; A O Verkerk; Z A Bhuiyan; A A M Wilde; H L Tan

Novel Brugada syndrome-causing mutation in ion-conducting pore of cardiac Na+ channel does not affect ion selectivity properties.

Authors

Amin, A S
Verkerk, A O
Bhuiyan, Z A
Wilde, A A M
Tan, H L

Type

Published Article

Journal

Acta physiologica Scandinavica

Publication Date

Dec 01, 2005

Volume

185

Issue

4

Pages

291–301

Identifiers

PMID: 16266370

Source

Medline

License

Unknown

Abstract

This study shows no changes in ion selectivity properties of D1714G channel. However, the profoundly decreased current density associated with the D1714G mutation may explain the Brugada syndrome phenotype in our patient.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/03/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/16266370

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