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Novel Brugada syndrome-causing mutation in ion-conducting pore of cardiac Na+ channel does not affect ion selectivity properties.

Authors
  • Amin, A S
  • Verkerk, A O
  • Bhuiyan, Z A
  • Wilde, A A M
  • Tan, H L
Type
Published Article
Journal
Acta physiologica Scandinavica
Publication Date
Dec 01, 2005
Volume
185
Issue
4
Pages
291–301
Identifiers
PMID: 16266370
Source
Medline
License
Unknown

Abstract

This study shows no changes in ion selectivity properties of D1714G channel. However, the profoundly decreased current density associated with the D1714G mutation may explain the Brugada syndrome phenotype in our patient.

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