Novel Brugada syndrome-causing mutation in ion-conducting pore of cardiac Na+ channel does not affect ion selectivity properties.
- Authors
- Type
- Published Article
- Journal
- Acta physiologica Scandinavica
- Publication Date
- Dec 01, 2005
- Volume
- 185
- Issue
- 4
- Pages
- 291–301
- Identifiers
- PMID: 16266370
- Source
- Medline
- License
- Unknown
Abstract
This study shows no changes in ion selectivity properties of D1714G channel. However, the profoundly decreased current density associated with the D1714G mutation may explain the Brugada syndrome phenotype in our patient.