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A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.

Authors
  • Guzmán, Esther A
  • Johnson, Jacob D
  • Linley, Patricia A
  • Gunasekera, Sarath E
  • Wright, Amy E
Type
Published Article
Journal
Investigational New Drugs
Publisher
Springer-Verlag
Publication Date
Oct 01, 2011
Volume
29
Issue
5
Pages
777–785
Identifiers
DOI: 10.1007/s10637-010-9422-6
PMID: 20352293
Source
Medline
License
Unknown

Abstract

Manzamine A appears to have a formerly unrecognized activity in blocking tumor cell invasion as well as in restoring cancer cell susceptibility to apoptosis in vitro and therefore has the potential to be used as an adjuvant to existing cancer therapies.

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