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A novel 3D bioprinted flexible and biocompatible hydrogel bioelectronic platform.

Authors
  • Agarwala, Shweta1
  • Lee, Jia Min1
  • Ng, Wei Long1
  • Layani, Michael2
  • Yeong, Wai Yee3
  • Magdassi, Shlomo4
  • 1 Singapore Centre for 3D Printing (SC3DP), Mechanical and Aerospace Engineering, Nanyang Technological University (NTU), 50 Nanyang Avenue, 639798, Singapore. , (Singapore)
  • 2 School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. , (Singapore)
  • 3 Singapore Centre for 3D Printing (SC3DP), Mechanical and Aerospace Engineering, Nanyang Technological University (NTU), 50 Nanyang Avenue, 639798, Singapore. Electronic address: [email protected] , (Singapore)
  • 4 Institute of Chemistry, Casali Center for Applied Chemistry, The Hebrew University of Jerusalem, 91904, Israel. , (Israel)
Type
Published Article
Journal
Biosensors & bioelectronics
Publication Date
Apr 15, 2018
Volume
102
Pages
365–371
Identifiers
DOI: 10.1016/j.bios.2017.11.039
PMID: 29172145
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Bioelectronics platforms are gaining widespread attention as they provide a template to study the interactions between biological species and electronics. Decoding the effect of the electrical signals on the cells and tissues holds the promise for treating the malignant tissue growth, regenerating organs and engineering new-age medical devices. This work is a step forward in this direction, where bio- and electronic materials co-exist on one platform without any need for post processing. We fabricate a freestanding and flexible hydrogel based platform using 3D bioprinting. The fabrication process is simple, easy and provides a flexible route to print materials with preferred shapes, size and spatial orientation. Through the design of interdigitated electrodes and heating coil, the platform can be tailored to print various circuits for different functionalities. The biocompatibility of the printed platform is tested using C2C12 murine myoblasts cell line. Furthermore, normal human dermal fibroblasts (primary cells) are also seeded on the platform to ascertain the compatibility. Copyright © 2017 Elsevier B.V. All rights reserved.

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