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A novel 203 kD aberrant BCR-ABL product in a girl with Philadelphia chromosome positive acute lymphoblastic leukaemia.

Authors
  • Inukai, T
  • Sugita, K
  • Suzuki, T
  • Ijima, K
  • Goi, K
  • Tezuka, T
  • Kojika, S
  • Hatakeyama, K
  • Kagami, K
  • Mori, T
Type
Published Article
Journal
British journal of haematology
Publication Date
Dec 01, 1993
Volume
85
Issue
4
Pages
823–825
Identifiers
PMID: 7918054
Source
Medline
License
Unknown

Abstract

We report a girl with Ph1-positive ALL with the aberrant BCR-ABL product. In this case, bcr exon 3 jointed not to ordinal abl exon 2 but to exon 3 resulting in the production of a 203 kD BCR-ABL fusion protein with marked tyrosine kinase activity. To our knowledge, this is the first report of an aberrant BCR-ABL product in childhood. This case was characterized with younger age and low leucocyte count at the onset, but relapsed early like the typical Ph1-positive ALL, suggesting the diversity in the clinicopathogenesis of Ph1-positive ALL.

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