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Nosocomial infection with vancomycin-dependent enterococci.

Authors
  • Tambyah, Paul A
  • Marx, John A
  • Maki, Dennis G
Type
Published Article
Journal
Emerging infectious diseases
Publication Date
Jul 01, 2004
Volume
10
Issue
7
Pages
1277–1281
Identifiers
PMID: 15324549
Source
Medline
License
Unknown

Abstract

We report three patients infected with unique strains of vancomycin-dependent enterococci. Two were first infected by genetically identical strains of vancomycin-resistant enterococci (VRE). All three patients had much greater exposure to vancomycin and third-generation cephalosporins than did two control groups (patients infected with VRE and hospitalized patients without enterococcal infections). While antimicrobial pressure promotes nosocomial colonization by VRE, prolonged exposure to vancomycin may foster the transition from vancomycin resistance to dependence.

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