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Nortriptyline pharmacokinetics and plasma levels: implications for clinical practice.

Authors
  • Rubin, E H
  • Biggs, J T
  • Preskorn, S H
Type
Published Article
Journal
The Journal of clinical psychiatry
Publication Date
Oct 01, 1985
Volume
46
Issue
10
Pages
418–424
Identifiers
PMID: 3900052
Source
Medline
License
Unknown

Abstract

The pharmacokinetics of TCAs are reviewed with particular emphasis on nortriptyline, the agent most extensively studied. The clinical uses of TCA plasma level-response studies are discussed in relationship to rational dosage adjustment to increase response rates and avoid iatrogenic toxicity. Other important topics discussed include the issue of active metabolites, single-dose prediction studies, and special considerations in treating the elderly and the medically ill.

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