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Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients.

Authors
  • Dalal, M A
  • Schuld, A
  • Haack, M
  • Uhr, M
  • Geisler, P
  • Eisensehr, I
  • Noachtar, S
  • Pollmächer, T
Type
Published Article
Journal
Neurology
Publication Date
Jun 26, 2001
Volume
56
Issue
12
Pages
1749–1751
Identifiers
PMID: 11425946
Source
Medline
License
Unknown

Abstract

Deficient orexin signaling has been shown to cause narcolepsy-like conditions in animals. In human narcolepsy, CSF levels of orexin A (hypocretin-1) were reported to be low in most cases. The authors measured CSF and plasma orexin A levels in patients with narcolepsy and in controls. Confirming earlier studies, they found CSF orexin A levels to be extremely low in patients with narcolepsy. However, plasma orexin A levels did not differ from those observed in controls. These results suggest that orexin deficiency in patients with narcolepsy is a phenomena restricted to the CNS.

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