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Normal mice express idiotypes related to autoantibody idiotypes of lupus mice

Authors
  • Syamal K. Datta
  • B. David Stollar
  • Robert S. Schwartz
Publication Date
May 01, 1983
Source
PMC
Keywords
License
Unknown

Abstract

Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.

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