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Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD.

Authors
Type
Published Article
Journal
Annals of the New York Academy of Sciences
Publication Date
Volume
1071
Pages
521–524
Identifiers
PMID: 16891611
Source
Medline

Abstract

Intrusive memories resulting from an emotional trauma are a defining feature of posttraumatic stress disorder (PTSD). Existing studies demonstrate that an increase of noradrenergic activity during a life-threatening event contributes to strengthening or "overconsolidation" of the memory for trauma. The lateral nucleus of the amygdala (LA) is critical for fear learning. Using classical fear conditioning in rats, we have recently demonstrated that noradrenergic blockade in the LA following reactivation of fear memory by retrieval disrupts memory reconsolidation and lastingly impairs fear memory. This suggests that noradrenergic blockade may be useful in attenuating traumatic memories, even well-consolidated old memories, in PTSD.

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