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Nonylphenol Ethoxylates, but Not Nonylphenol, Are Substrates of the Human Multidrug Resistance P-glycoprotein

Authors
  • Loo, Tip W.
  • Clarke, David M.
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Publication Date
Jan 01, 1998
Volume
247
Issue
2
Pages
478–480
Identifiers
DOI: 10.1006/bbrc.1998.8823
Source
Elsevier
Keywords
License
Unknown

Abstract

Alkylphenol ethoxylates are surfactants that are commonly used in industry and in home care products. They are broken down by anaerobes to yield toxic environmental pollutants such as nonylphenol. In this study, we tested whether nonylphenol ethoxylates and their most common biodegradation product, nonylphenol, were substrates of human P-glycoprotein.In vivoandin vitroassays showed that the enzyme interacts with a wide variety of nonylphenol ethoxylate compounds, but not with nonylphenol. These results suggest that P-glycoprotein can protect organisms from the toxic and estrogenic effects of nonylphenol ethoxylates, but not from the major biodegradation product, nonylphenol.

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