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Nontoxic-dose deoxynivalenol aggravates lipopolysaccharides-induced inflammation and tight junction disorder in IPEC-J2 cells through activation of NF-κB and LC3B

Authors
  • Ge, Lei1, 2, 3
  • Lin, Ziman1, 2, 3
  • Le, Guannan1, 2, 3
  • Hou, Lili1, 2, 3
  • Mao, Xinru1, 2, 3
  • Liu, Shuiping1, 2, 3
  • Liu, Dandan1, 2, 3
  • Gan, Fang1, 2, 3
  • Huang, Kehe1, 2, 3
  • 1 College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China
  • 2 Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China
  • 3 MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China
Type
Published Article
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Publication Date
Aug 30, 2020
Volume
145
Pages
111712–111712
Identifiers
DOI: 10.1016/j.fct.2020.111712
PMID: 32877744
PMCID: PMC7456579
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Nontoxic-dose DON aggravates LPS-induced cellular inflammatory response in IPEC-J2 cell monolayers. • Nontoxic-dose DON aggravates LPS-induced decrease and distribution disorder of tight junction in IPEC-J2 cell monolayers. • Nontoxic-dose DON aggravates LPS-induced inflammatory response and tight junction disorder by activating NF-κB and LC3B.

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