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Nonsteroidal antiinflammatory drugs and certain rare, serious adverse events: a cohort study.

Authors
Type
Published Article
Journal
Pharmacotherapy
Publication Date
Volume
13
Issue
3
Pages
212–217
Identifiers
PMID: 8321735
Source
Medline
License
Unknown

Abstract

We performed a population-based study of over 100,000 users of diclofenac, naproxen, or piroxicam to identify cases of important blood, skin, central nervous system, kidney, pancreas, or pulmonary disorders caused by these drugs. In three cases a causal relation seemed likely; one of hemolytic anemia attributed to diclofenac, one of neutropenia attributed to naproxen, and one of pancreatitis attributed to piroxicam. In 13 additional cases a causal connection seemed unlikely but could not be fully ruled out. We conclude that such illnesses are uncommonly caused by the three agents studied.

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