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Non-SARS, non-MERS human coronavirus infections and risk of Kawasaki disease: a meta-analysis

Authors
  • Patra, Pratap Kumar
  • Das, Rashmi Ranjan
  • Banday, Aaqib Zaffar
  • Singh, Mini
  • Goyal, Kapil
  • Jindal, Ankur Kumar
  • Singh, Surjit
Type
Published Article
Journal
Future Virology
Publisher
Future Medicine
Publication Date
Nov 26, 2021
Identifiers
DOI: 10.2217/fvl-2021-0176
PMID: 34858515
PMCID: PMC8629369
Source
PubMed Central
Keywords
Disciplines
  • Meta-Analysis
License
Unknown

Abstract

Aim: To study the association between non-SARS, non-MERS human coronavirus (HCoV) infections and Kawasaki disease (KD). Methods: Meta-analysis of observational studies published until 1 May 2021. Results: Out of 571 papers retrieved through database search, 10 provided data of 17,732 children. Age ranged from 2 months–14.9 years with 66% being male and 71% being complete KD. Compared with controls, there was an increased risk of developing KD in those detected to have HCoV infection (OR: 2.3 [95% CI: 1.06–4.99]; p = 0.03). The GRADE evidence for all outcomes was of ‘low-certainty’. Conclusion: A ‘low certainty’ of evidence suggests an increased risk of KD in children infected with HCoV. We need multi-center, prospective studies to support or refute this finding. PROSPERO protocol registration : CRD42021251582.

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