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Nonrandom distribution of repeated DNA sequences with respect to supercoiled loops and the nuclear matrix.

Authors
  • D Small
  • B Nelkin
  • B Vogelstein
Publication Date
Oct 01, 1982
Source
PMC
Keywords
License
Unknown

Abstract

The DNA in a eukaryotic nucleus is arranged into a series of supercoiled loops that are anchored at their bases to the nuclear matrix. We have analyzed the DNA sequences that are closest to the matrix attachment points for their relative content of specific repeated sequences. Sequences were enriched (mouse satellite, human Alu family) or depleted (mouse EcoRI repeat, monkey alpha component), depending on the specific sequence and species examined. These results can be understood in terms of a nonrandom arrangement of DNA sequences with respect to nuclear DNA loops.

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