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Non-negative Matrix Factorization Reveals Resting-State Cortical Alpha Network Abnormalities in the First-Episode Schizophrenia Spectrum.

Authors
  • Phalen, Henry1
  • Coffman, Brian A2
  • Ghuman, Avniel3
  • Sejdić, Ervin4
  • Salisbury, Dean F5
  • 1 Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • 2 Clinical Neurophysiology Research Laboratory, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • 3 Laboratory of Cognitive Neurodynamics, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • 4 Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • 5 Clinical Neurophysiology Research Laboratory, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address: [email protected]
Type
Published Article
Journal
Biological psychiatry. Cognitive neuroscience and neuroimaging
Publication Date
Oct 01, 2020
Volume
5
Issue
10
Pages
961–970
Identifiers
DOI: 10.1016/j.bpsc.2019.06.010
PMID: 31451387
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Little is known about neural oscillatory dynamics in first-episode psychosis. Pathophysiology of functional connectivity can be measured through network activity of alpha oscillations, reflecting long-range communication between distal brain regions. Resting magnetoencephalographic activity was collected from 31 individuals with first-episode schizophrenia spectrum psychosis and 22 healthy control individuals. Activity was projected to the realistic cortical surface, based on structural magnetic resonance imaging. The first principal component of activity in 40 Brodmann areas per hemisphere was Hilbert transformed within the alpha range. Non-negative matrix factorization was applied to single-trial alpha phase-locking values from all subjects to determine alpha networks. Within networks, energy and entropy were compared. Four cortical alpha networks were pathological in individuals with first-episode schizophrenia spectrum psychosis. The networks involved the bilateral anterior and posterior cingulate; left auditory, medial temporal, and cingulate cortex; right inferior frontal gyrus and widespread areas; and right posterior parietal cortex and widespread areas. Energy and entropy were associated with the Positive and Negative Syndrome Scale total and thought disorder factors for the first three networks. In addition, the left posterior temporal network was associated with positive and negative factors, and the right inferior frontal network was associated with the positive factor. Machine learning network analysis of resting alpha-band neural activity identified several aberrant networks in individuals with first-episode schizophrenia spectrum psychosis, including the left temporal, right inferior frontal, right posterior parietal, and bilateral cingulate cortices. Abnormal long-range alpha communication is evident at the first presentation for psychosis and may provide clues about mechanisms of dysconnectivity in psychosis and novel targets for noninvasive brain stimulation. Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

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