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Nonlinear mixed effects models applied to cumulative concentration-response curves.

Authors
  • Thorin, Chantal
  • Mallem, Mohamed Yassine
  • Noireaud, Jacques
  • Gogny, Marc
  • Desfontis, Jean-Claude
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Mar 01, 2010
Volume
62
Issue
3
Pages
339–345
Identifiers
DOI: 10.1211/jpp.62.03.0008
PMID: 20487217
Source
Medline
License
Unknown

Abstract

Using the method presently described, it is now possible to detect significant differences for each pharmacological parameter estimated in different situations, even for designs with small samples size (i.e. at least six complete curves).

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