The evaluation, treatment, and disposition of patients with symptoms suggestive of acute coronary syndrome (ACS) in the Emergency Department continues to be a clinical challenge. Many patients with suggestive symptoms are admitted to the hospital to rule out a myocardial infarction by serial enzyme tests and EKGs and receive an expedited work-up for ischemia. However, the diagnosis can be difficult, given the wide range of potentially atypical symptoms that can signal ACS, which remains a major clinical risk for patients and a liability risk for emergency physicians. This article reviews imaging technologies such as echocardiography and nuclear perfusion imaging used currently in the diagnosis of ACS and rapidly advancing technologies such as CT and MRI that may be able to visualize calcifications, plaques, occlusions, and infarctions noninvasively in real time. Some noninvasive tests used to complete an ischemia work-up after serial enzyme testing and EKGs, such as exercise EKG, stress echocardiography, and stress perfusion imaging, also are reviewed.