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Nonintercalative binding of ethidium bromide to nucleic acids: crystal structure of an ethidium--tRNA molecular complex.

Authors
Type
Published Article
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publication Date
Volume
74
Issue
11
Pages
4821–4825
Identifiers
PMID: 270714
Source
Medline
License
Unknown

Abstract

X-ray diffraction studies at 4.5-A resolution on crystals of a complex of ethidium bromide and yeast phenylalanine tRNA reveal a nonintercalative model of binding of the ethidium within the tertiary structure. This is contrary to the expected interacalative binding to the double-helical regions.

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