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Nonintercalative binding of ethidium bromide to nucleic acids: crystal structure of an ethidium--tRNA molecular complex.

Authors
  • Liebman, M
  • Rubin, J
  • Sundaralingam, M
Type
Published Article
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publication Date
Nov 01, 1977
Volume
74
Issue
11
Pages
4821–4825
Identifiers
PMID: 270714
Source
Medline
License
Unknown

Abstract

X-ray diffraction studies at 4.5-A resolution on crystals of a complex of ethidium bromide and yeast phenylalanine tRNA reveal a nonintercalative model of binding of the ethidium within the tertiary structure. This is contrary to the expected interacalative binding to the double-helical regions.

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