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Nonhydrolytic Pathway in Metabolism of N-Methylcarbamate Insecticides.

Authors
  • Dorough, H W
  • Leeling, N C
  • Casida, J E
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Apr 12, 1963
Volume
140
Issue
3563
Pages
170–171
Identifiers
PMID: 17819831
Source
Medline
License
Unknown

Abstract

Sevin (1-naphthyl N-methylcarbamate), when metabolized by rat liver microsomes and insects, yielded at least five carbamate metabolites involving modification of both the methyl group and ring. Certain of these metabolites appeared in milk when Sevin was fed to a goat. The metabolism of o-isopropoxyphenyl N-methylcarbamate by liver microsomes, insects, and plants was compared to that of Sevin.

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