Affordable Access

Nonhomogeneous deformation in the anterior leaflet of the mitral valve.

Authors
  • Chen, Ling
  • McCulloch, Andrew D
  • May-Newman, Karen
Type
Published Article
Journal
Annals of biomedical engineering
Publication Date
Dec 01, 2004
Volume
32
Issue
12
Pages
1599–1606
Identifiers
PMID: 15675673
Source
Medline
License
Unknown

Abstract

In the mitral valve, regional variations in structure and material properties combine to affect the biomechanics of the entire valve. Previous biaxial testing has shown that mitral valve leaflet tissue is highly extensible, and exhibits nonlinear, anisotropic material properties. In this study, experimental measurements of mitral valve leaflet deformation under quasi-static pressure loading were performed on isolated porcine hearts. Biplane video images of markers placed on the anterior leaflet surface were used to reconstruct the 3D position of the markers at several pressure levels over the physiological range. A least-squares finite-element method was used to fit parametric models to the markers and to calculate the deformation over the surface. The results showed that the leaflet deformations were anisotropic, exhibiting a large nonhomogeneous radial stretch and a small circumferential stretch. This information can be used to better understand how the valve deforms under physiological loading, and to help design treatments for valve problems, such as mitral regurgitation.

Report this publication

Statistics

Seen <100 times