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Non-coding RNAs as antibiotic targets.

Authors
  • Colameco, Savannah1
  • Elliot, Marie A2
  • 1 Department of Biology and Institute for Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. , (Canada)
  • 2 Department of Biology and Institute for Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address: [email protected] , (Canada)
Type
Published Article
Journal
Biochemical pharmacology
Publisher
New York, NY : Elsevier Science Inc
Publication Date
Jun 01, 2017
Volume
133
Pages
29–42
Identifiers
DOI: 10.1016/j.bcp.2016.12.015
PMID: 28012959
Source
Medline
Keywords
License
Unknown

Abstract

Antibiotics inhibit a wide range of essential processes in the bacterial cell, including replication, transcription, translation and cell wall synthesis. In many instances, these antibiotics exert their effects through association with non-coding RNAs. This review highlights many classical antibiotic targets (e.g. rRNAs and the ribosome), explores a number of emerging targets (e.g. tRNAs, RNase P, riboswitches and small RNAs), and discusses the future directions and challenges associated with non-coding RNAs as antibiotic targets.

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