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Non-mutagenic carcinogens are primarily hydrophobic.

Authors
  • McCoy, G D
  • Rosenkranz, H S
  • Klopman, G
Type
Published Article
Journal
Carcinogenesis
Publication Date
Jul 01, 1990
Volume
11
Issue
7
Pages
1111–1117
Identifiers
PMID: 2372870
Source
Medline
License
Unknown

Abstract

There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients than mutagenic ones. This property of non-mutagenic carcinogens may suggest that their ability to induce tumors is associated with membraneous receptor sites and/or a longer residence time in the animal.

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