Non-mutagenic carcinogens are primarily hydrophobic.
- Published Article
- Publication Date
Jul 01, 1990
There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients than mutagenic ones. This property of non-mutagenic carcinogens may suggest that their ability to induce tumors is associated with membraneous receptor sites and/or a longer residence time in the animal.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2372870