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Non-micro-short RNAs: the new kids on the block.

Authors
  • Dey, Bijan K1
  • Mueller, Adam C
  • Dutta, Anindya
  • 1 Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Type
Published Article
Journal
Molecular Biology of the Cell
Publisher
American Society for Cell Biology
Publication Date
Dec 01, 2012
Volume
23
Issue
24
Pages
4664–4667
Identifiers
DOI: 10.1091/mbc.E12-10-0716
PMID: 23239791
Source
Medline
License
Unknown

Abstract

The advent of ultra-high-throughput sequencing has led to the discovery of a large group of small, noncoding RNAs that are not microRNAs. The functional relevance of microRNAs has been well established over the last decade. In this Perspective, we focus on the non-micro-short RNAs that comprise a variety of functional classes and range from 16-40 nucleotides in size. We will highlight how some of these non-micro-short RNAs were discovered, as well as their biogenesis, potential mechanisms of action, and role in diverse biological processes, development, and disease. Finally, we will describe what must be done to further our understanding of these enigmatic molecules.

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