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Non-cell autonomous and non-catalytic activities of ATX in the developing brain.

Authors
  • Greenman, Raanan
  • Gorelik, Anna
  • Sapir, Tamar
  • Baumgart, Jan
  • Zamor, Vanessa
  • Segal-Salto, Michal
  • Levin-Zaidman, Smadar
  • Aidinis, Vassilis
  • Aoki, Junken
  • Nitsch, Robert
  • Vogt, Johannes
  • Reiner, Orly
Type
Published Article
Journal
Frontiers in Neuroscience
Publisher
Frontiers Media SA
Publication Date
Jan 01, 2015
Volume
9
Pages
53–53
Identifiers
DOI: 10.3389/fnins.2015.00053
PMID: 25788872
Source
Medline
Keywords
License
Unknown

Abstract

The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are well-studied, the non-cell autonomous mechanisms remain poorly understood. A non-biased screen allowed us to identify Autotaxin (ATX) as a non-cell autonomous regulator of neural stem cells. ATX (also known as ENPP2) is best known to catalyze lysophosphatidic acid (LPA) production. Our results demonstrate that ATX affects the localization and adhesion of neuronal progenitors in a cell autonomous and non-cell autonomous manner, and strikingly, this activity is independent from its catalytic activity in producing LPA.

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