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Non-alcoholic fatty liver disease proteomics.

Authors
  • Rodríguez-Suárez, Eva1
  • Duce, Antonio M
  • Caballería, Juan
  • Martínez Arrieta, Félix
  • Fernández, Estefanía
  • Gómara, Carolina
  • Alkorta, Nere
  • Ariz, Usue
  • Martínez-Chantar, M Luz
  • Lu, Shelly C
  • Elortza, Felix
  • Mato, José M
  • 1 Proteomics Platform, CIC bioGUNE, CIBERehd, ProteoRed, Technology Park of Bizkaia, Derio, Bizkaia, Spain. , (Spain)
Type
Published Article
Journal
PROTEOMICS - CLINICAL APPLICATIONS
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 01, 2010
Volume
4
Issue
4
Pages
362–371
Identifiers
DOI: 10.1002/prca.200900119
PMID: 21137056
Source
Medline
License
Unknown

Abstract

Following this approach we identified two candidate markers, carbamoyl phosphate synthase 1 and 78 kDa glucose-regulated protein, differentially expressed between control and NASH. This proteomics approach demonstrates that DIGE combined with MALDI TOF/TOF and Western blot analysis of tissue and serum samples is a useful approach to identify candidate markers associated with NAFLD, resulting in proteins whose level of expression can be correlated to a disease state.

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