Noise buffering by biomolecular condensates in glucose sensing.
The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Ramat Aviv, 69978, Israel.
The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Ramat Aviv, 69978, Israel. Electronic address: [email protected]
- Published Article
Current opinion in cell biology
- Publication Date
Dec 31, 2020
Many cellular processes involve buffering mechanisms against noise to enhance state stability. Such processes include the cell cycle and the switch between respiration and fermentation. In recent years, protein aggregation/condensation has emerged as an important regulatory mechanism. In this article, we examine the regulation of Std1, an activator of the Snf1/AMPK kinase, by sequestration into foci of liquid drops, and how foci of metabolic signaling and enzymatic proteins are regulated by chaperones, anti-aggregases and by phosphorylation. Copyright © 2020 Elsevier Ltd. All rights reserved.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/33388622