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Nocturia in patients with cognitive dysfunction: a systematic review of the literature

  • Haddad, Rebecca1, 2
  • Monaghan, Thomas F.1, 3
  • Joussain, Charles4, 5
  • Phé, Véronique6
  • Bower, Wendy7
  • Roggeman, Saskia1
  • Robain, Gilberte2
  • Everaert, Karel1
  • 1 Ghent University Hospital, Corneel Heymanslaan 10, Ghent, 9000, Belgium , Ghent (Belgium)
  • 2 Sorbonne Université Rothschild Academic Hospital AP-HP, Paris, F-75012, France , Paris (France)
  • 3 SUNY Downstate Medical Center, Brooklyn, NY, USA , Brooklyn (United States)
  • 4 Versailles Saint-Quentin University, Versailles, France , Versailles (France)
  • 5 Raymond-Poincaré Academic Hospital AP-HP, Garches, France , Garches (France)
  • 6 Sorbonne Université Pitié-Salpêtrière Academic Hospital AP-HP, Paris, France , Paris (France)
  • 7 The University of Melbourne, Melbourne, Australia , Melbourne (Australia)
Published Article
BMC Geriatrics
BioMed Central
Publication Date
Jul 06, 2020
DOI: 10.1186/s12877-020-01622-8
Springer Nature


BackgroundThe objective of this study is to evaluate current literature on the association between cognitive dysfunction and nocturia.MethodsA systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was conducted through MEDLINE, EMBASE and COCHRANE databases and completed in November 2019. Randomized and non-randomized studies were included if they assessed the association between cognitive dysfunction and nocturia in older participants with or without neurological diseases. The quality of included studies was evaluated using the Risk of Bias Assessment tool for Non-randomized Studies (RoBANS).ResultsA total of 8 cross-sectional studies conducted in older patient populations met the criteria for inclusion. A statistically significant association was identified in 6 studies on univariate analysis, which persisted in 2 studies after controlling for confounding factors. The association between cognitive dysfunction and nocturia was positive for all 6 significant analyses. The overall risk of bias was unclear.ConclusionA significant positive association between cognitive dysfunction and nocturia was identified. However, research has been limited to cross-sectional studies, which precludes identification of causality between cognitive dysfunction and nocturia. Heightened awareness of the complex interplay between cognition and nocturia would allow professionals involved in the care of cognitively impaired patients with concomitant nocturia to more effectively manage these symptoms.

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