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Nociceptin: an endogenous agonist for central opioid like1 (ORL1) receptors possesses systemic vasorelaxant properties.

Authors
  • Gumusel, B1
  • Hao, Q
  • Hyman, A
  • Chang, J K
  • Kapusta, D R
  • Lippton, H
  • 1 HL Labs, Inc., New Orleans, LA 70112, USA.
Type
Published Article
Journal
Life Sciences
Publisher
Elsevier
Publication Date
1997
Volume
60
Issue
8
Identifiers
PMID: 9042395
Source
Medline
License
Unknown

Abstract

The purpose of the present study was to investigate the effects of nociceptin on peripheral arterial rings from the cat. When feline renal, mesenteric, carotid and femoral rings with intact endothelium were precontracted with phenylephrine (100 nanomolar), nociceptin (3 x 10(-11)-3 x 10(-6) M) decreased tension in a concentration-dependent manner. The present data suggest nociceptin possesses biologic activity outside the CNS and may contribute to the regulation of systemic blood pressure and regional blood flow.

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