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NMR difference probe: a dual-coil probe for NMR difference spectroscopy.

Authors
Type
Published Article
Journal
Journal of magnetic resonance (San Diego, Calif. : 1997)
Publication Date
Volume
156
Issue
1
Pages
97–103
Identifiers
PMID: 12081446
Source
Medline
License
Unknown

Abstract

A unique probe designed to acquire nuclear magnetic resonance difference spectra of two samples is presented. The NMR Difference Probe contains two sample coils in a resonant circuit that switches between parallel excitation and serial acquisition to cancel common signals such as solvent peaks and impurities. Two samples containing a common analyte, acetonitrile, were used to demonstrate signal cancellation in a difference spectrum collected with a single pulse experiment. The cancellation was over 96% effective. The approach described has applications in the areas of solvent subtraction and spectral simplification.

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