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NMR analysis of tautomerisms of active pinacidil-type potassium channel openers and a less active one.

Authors
  • Yoshiizumi, K
  • Nakajima, F
  • Kiyoi, T
  • Kondo, H
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Nov 06, 2000
Volume
10
Issue
21
Pages
2463–2466
Identifiers
PMID: 11078201
Source
Medline
License
Unknown

Abstract

In order to clarify the structural difference between active pinacidil-type potassium channel openers and a less active one, the tautomerisms of pinacidil derivatives 1-3 were investigated by NMR spectrometries. The predominant tautomer of the less active compound 3 was different from those of the active compounds 1 and 2.

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