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N-Methyl-D-Aspartate Receptors Mediate Excitotoxicity in Amyloid Beta-Induced Synaptic Pathology of Alzheimer’s Disease

Authors
  • Liu, Jinping
  • Gao, Xiulai
  • Wu, Yan
Type
Published Article
Journal
Neuroembryology and Aging
Publisher
S. Karger AG
Publication Date
Jan 20, 2009
Volume
5
Issue
4
Pages
134–143
Identifiers
DOI: 10.1159/000193851
Source
Karger
Keywords
License
Green
External links

Abstract

Mounting evidence suggests that cognitive impairment begins with subtle alterations of synaptic efficacy prior to frank neuronal degeneration, and synaptic dysfunction may be induced by diffusible oligomeric assemblies of amyloid beta peptide (Aβ). The mechanisms underlying Aβ neurotoxicity are complex but might involve N-methyl-D-aspartate receptor (NMDAR). This review focuses on the action of NMDAR and its subunits in Aβ-induced synaptic dysfunction. The localized apoptotic mechanism that contributes to synaptic dysfunction in Alzheimer’s disease will also be discussed.

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