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The NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltage-operated Ca2+ channels in rat cultured cortical neurons.

Authors
  • Biton, B
  • Granger, P
  • Carreau, A
  • Depoortere, H
  • Scatton, B
  • Avenet, P
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
May 23, 1994
Volume
257
Issue
3
Pages
297–301
Identifiers
PMID: 8088348
Source
Medline
License
Unknown

Abstract

The effect of the non-competitive NMDA receptor antagonist eliprodil on NMDA receptor- and voltage-operated Ca2+ currents was investigated in rat cultured cortical neurons by using the whole-cell patch clamp technique. With neurons voltage-clamped at -40 mV, eliprodil reduced in a concentration-dependent manner the inward current induced by N-methyl-D-aspartate (NMDA) (10 microM) in the presence of D-serine with an IC50 of 0.67 microM (Imax = 83%). Eliprodil also blocked the total inward Ba2+ current carried in part by L- and N-type Ca2+ channels with an IC50 of 1.48 microM (Imax = 87%). These results suggest that the neuroprotective properties of eliprodil could be due to its combined ability to antagonize the NMDA receptor- and voltage-operated Ca2+ channels.

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