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NKG7 makes a better killer

Authors
  • Malarkannan, Subramaniam1, 2, 2, 2
  • 1 Blood Research Institute, Versiti, Milwaukee, WI, USA , Milwaukee (United States)
  • 2 Medical College of Wisconsin, Milwaukee, WI, USA , Milwaukee (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 24, 2020
Volume
21
Issue
10
Pages
1139–1140
Identifiers
DOI: 10.1038/s41590-020-0767-5
Source
Springer Nature
License
Yellow

Abstract

New studies suggest that NKG7 is essential for NK and CD8+ T cell cytotoxic degranulation and CD4+ T cell activation and proinflammatory responses. While the mechanism is yet to be determined, the functional relevance is exciting and opens the possibility of a new target for cellular immunotherapies.

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