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NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain.

Authors
  • Deb, Chandra
  • Howe, Charles L
Type
Published Article
Journal
Journal of NeuroVirology
Publisher
Springer-Verlag
Publication Date
May 01, 2008
Volume
14
Issue
3
Pages
261–266
Identifiers
DOI: 10.1080/13550280802105002
PMID: 18569460
Source
Medline
License
Unknown

Abstract

Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the clearance of central nervous system viral infections has not been explored. Using the Theiler's murine encephalomyelitis virus model, the authors found that NKG2D-positive CD8+ cytotoxic T cells enter the brain, that NKG2D ligands are expressed in the brain during acute infection, and that interruption of NKG2D ligand recognition via treatment with a function-blocking antibody attenuates the efficacy of viral clearance from the central nervous system.

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