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The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Authors
  • Ng, Susanna S.1, 2, 3
  • De Labastida Rivera, Fabian1
  • Yan, Juming1, 4
  • Corvino, Dillon1, 4, 3
  • Das, Indrajit1
  • Zhang, Ping1
  • Kuns, Rachel1
  • Chauhan, Shashi Bhushan5
  • Hou, Jiajie1
  • Li, Xian-Yang1
  • Frame, Teija C. M.1, 4
  • McEnroe, Benjamin A.1
  • Moore, Eilish1, 4
  • Na, Jinrui1, 4
  • Engel, Jessica A.1
  • Soon, Megan S. F.1, 4
  • Singh, Bhawana5
  • Kueh, Andrew J.6, 7
  • Herold, Marco J.6, 7
  • Montes de Oca, Marcela1
  • And 29 more
  • 1 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia , Brisbane (Australia)
  • 2 School of Environment and Science, Griffith University, Nathan, Queensland, Australia , Nathan (Australia)
  • 3 University of Bonn, Bonn, Germany , Bonn (Germany)
  • 4 University of Queensland, Brisbane, Queensland, Australia , Brisbane (Australia)
  • 5 Banaras Hindu University, Varanasi, India , Varanasi (India)
  • 6 Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia , Melbourne (Australia)
  • 7 University of Melbourne, Melbourne, Victoria, Australia , Melbourne (Australia)
  • 8 Griffith University, Gold Coast, Queensland, Australia , Gold Coast (Australia)
  • 9 James Cook University, Townsville, Queensland, Australia , Townsville (Australia)
  • 10 James Cook University, Cairns, Queensland, Australia , Cairns (Australia)
  • 11 University of Auckland, Auckland, New Zealand , Auckland (New Zealand)
  • 12 Monash University, Melbourne, Victoria, Australia , Melbourne (Australia)
  • 13 Lions Eye Institute, Perth, Western Australia, Australia , Perth (Australia)
  • 14 University of Manitoba, Winnipeg, Manitoba, Canada , Winnipeg (Canada)
  • 15 Fred Hutchinson Cancer Research Center, Seattle, WA, USA , Seattle (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 24, 2020
Volume
21
Issue
10
Pages
1205–1218
Identifiers
DOI: 10.1038/s41590-020-0758-6
Source
Springer Nature
License
Yellow

Abstract

NKG7 is a molecule well associated with NK cells but of unknown function. Engwerda and colleagues demonstrate that NKG7 is also associated with TH1 cells and is essential for type I and cytotoxic responses.

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